EPS8L1

Across TCGA pan-cancer cohorts, EPS8L1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of EPS8L1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where EPS8L1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EPS8L1 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

PDAC, CCRCC, and COAD are the cancer types where EPS8L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPS8L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	III,IV	+1.142	<.001	11	view →
CCRCC	Male	III,IV	−0.997	<.001	11	view →
COAD	All	II,III,IV	+0.286	<.001	9	view →
HNSC	Male	IV	−1.489	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

EPS8L1–PDAC

Open the PDAC breakdown →