EPS8L1

Across TCGA patient cohorts, EPS8L1 mutation is significantly associated with the RNA expression of many other genes, with 3,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPS8L1-associated genes across cancer lineages are BORCS7-ASMT, COX15, and CPSF7. Each is linked with EPS8L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPS8L1-to-partner and partner-to-EPS8L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BORCS7-ASMT grouped by EPS8L1-low versus EPS8L1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8L1→partner) and Y-score (partner→EPS8L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	BORCS7-ASMT →	+0.015	+4.588	<.001	<.001	3	3
UCEC	COX15 →	+0.327	+2.275	.002	.005	3	2
UCEC	CPSF7 →	+0.331	+1.839	<.001	<.001	3	2
UCEC	NCAPD3 →	+0.601	+1.818	<.001	<.001	3	2
UCEC	BAG3 →	+0.655	+2.050	<.001	<.001	3	2
UCEC	C18orf25 →	+0.331	+1.864	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,403 associations by consensus.

BORCS7-ASMT by EPS8L1 expression — BLCA

Explore this box plot interactively →