EPS8L1

Across TCGA patient cohorts, EPS8L1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPS8L1-associated genes across cancer lineages are eIF4E, eIF4G, and MEK1. Each is linked with EPS8L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPS8L1-to-partner and partner-to-EPS8L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EPS8L1-low versus EPS8L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8L1→partner) and Y-score (partner→EPS8L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.243	+3.169	<.001	<.001	3	2
UCEC	eIF4G →	+0.269	+2.459	.007	.018	3	2
UCEC	MEK1 →	+0.342	+1.847	.003	.007	3	2
COAD	Rad50 →	-0.302	-2.296	.002	.033	3	2
UCEC	ATM →	-0.630	-2.571	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.286	-2.700	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by EPS8L1 expression — UCEC

Explore this box plot interactively →