EPS8

Across TCGA pan-cancer cohorts, EPS8 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EPS8 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher EPS8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPS8 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

ESCA, LGG, and BRCA are the cancer types where EPS8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.080	0.533	<.001	18	view →
LGG	OS	Median	All	0.187	0.909	<.001	12	view →
BRCA	OS	Median	III,IV	0.579	0.906	.035	6	view →
ACC	DFS	Median	All	0.140	0.666	.049	3	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →
UCEC	DFS	Median	All	0.949	0.828	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EPS8–ESCA (DFS)

Open the ESCA breakdown →