EPS8

Across TCGA pan-cancer cohorts, EPS8 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of EPS8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EPS8 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EPS8 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

COAD, PDAC, and HNSC are the cancer types where EPS8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPS8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.295	<.001	11	view →
PDAC	Male	All	+0.664	<.001	7	view →
HNSC	Male	II,III,IV	−0.357	<.001	6	view →
LSCC	All	All	−0.236	<.001	5	view →
LUAD	All	All	+0.131	.001	3	view →
OV	All	All	−0.627	.006	2	view →
CCRCC	Male	All	+0.081	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

EPS8–COAD

Open the COAD breakdown →