EPS8

Across TCGA cell cohorts, EPS8 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,305 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EPS8-associated GO terms across cancer lineages are Barbed-end actin filament capping, Actin filament capping, and Positive regulation of ruffle assembly. Each is linked with EPS8 in more than 13 cancer types. Because this analysis shows association rather than direction, both EPS8-to-partner and partner-to-EPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Barbed-end actin filament capping grouped by EPS8-low versus EPS8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8→partner) and Y-score (partner→EPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Barbed-end actin filament capping →	+0.221	+1.386	<.001	.004	3	14
LUNG_NSCLC_LUAD	Actin filament capping →	+0.187	+1.712	<.001	<.001	3	13
BONE	Positive regulation of ruffle assembly →	+0.239	+2.394	<.001	<.001	3	13
PANCREAS	Negative regulation of actin filament polymerization →	+0.172	+1.969	<.001	<.001	3	12
STOMACH	Regulation of Rho protein signal transduction →	+0.092	+1.822	.004	<.001	3	12
BONE	Regulation of actin filament depolymerization →	+0.193	+2.763	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,305 associations by consensus.

Barbed-end actin filament capping by EPS8 expression — BONE

Explore this box plot interactively →