EPS8

Across TCGA cell cohorts, EPS8 mutation is significantly associated with the RNA expression of many other genes, with 364 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPS8-associated genes across cancer lineages are RIC1, CRBN, and GPR182. Each is linked with EPS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPS8-to-partner and partner-to-EPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIC1 grouped by EPS8-low versus EPS8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPS8→partner) and Y-score (partner→EPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RIC1 →	+0.574	+2.502	.005	.005	3	2
LARGE_INTESTINE	CRBN →	+0.456	+3.421	<.001	.002	3	2
LARGE_INTESTINE	GPR182 →	+0.081	+2.478	.007	.006	3	2
LARGE_INTESTINE	PROP1 →	+0.017	+2.276	<.001	.001	3	2
SKIN	PATE1 →	+0.036	+2.878	<.001	.009	3	2
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 364 associations by consensus.

RIC1 by EPS8 expression — LARGE_INTESTINE

Explore this box plot interactively →