EPS15L1

Across TCGA pan-cancer cohorts, EPS15L1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of EPS15L1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EPS15L1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types EPS15L1 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where EPS15L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPS15L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.184	<.001	11	view →
CCRCC	Male	All	−0.257	<.001	10	view →
LSCC	Female	II,III,IV	−0.347	<.001	9	view →
LUAD	Male	II,III,IV	−0.179	<.001	8	view →
HNSC	Male	II,III,IV	−0.125	<.001	8	view →
PDAC	Female	All	+0.177	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

EPS15L1–COAD

Open the COAD breakdown →