EPRS1

Across TCGA patient cohorts, EPRS1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPRS1-associated genes across cancer lineages are Caspase-7-cleavedD198, ACVRL1, and ATM. Each is linked with EPRS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPRS1-to-partner and partner-to-EPRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EPRS1-low versus EPRS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPRS1→partner) and Y-score (partner→EPRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.551	+1.925	.001	.004	3	4
UCEC	ACVRL1 →	-0.109	-1.395	.005	.008	3	3
UCEC	ATM →	-0.426	-2.074	<.001	.004	3	3
STAD	Annexin_VII →	-0.219	-3.000	.004	.033	3	2
STAD	Chk2 →	+0.362	+3.000	.013	.034	3	2
STAD	C-Raf →	+0.238	+3.321	.001	.010	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by EPRS1 expression — UCEC

Explore this box plot interactively →