EPRS1

Across TCGA cell cohorts, EPRS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,838 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPRS1-associated GO terms across cancer lineages are Regulation of formation of translation preinitiation complex, Negative regulation of formation of translation preinitiation complex, and Negative regulation of cytoplasmic translational initiation. Each is linked with EPRS1 in more than 15 cancer types. Because this analysis shows association rather than direction, both EPRS1-to-partner and partner-to-EPRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of formation of translation preinitiation complex grouped by EPRS1-low versus EPRS1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPRS1→partner) and Y-score (partner→EPRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of formation of translation preinitiation complex →	+0.092	+0.735	<.001	<.001	3	16
LUNG_SCLC	Negative regulation of formation of translation preinitiation complex →	+0.092	+0.735	<.001	<.001	3	16
SKIN	Negative regulation of cytoplasmic translational initiation →	+0.092	+0.463	<.001	<.001	3	16
BLOOD_Lymphoma	Establishment of protein localization to endoplasmic reticulum membrane →	+0.115	+0.729	<.001	<.001	3	16
LARGE_INTESTINE	Formate biosynthetic process →	+0.128	+0.626	<.001	<.001	3	11
OVARY	Positive regulation of rRNA processing →	+0.119	+0.736	.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,838 associations by consensus.

Regulation of formation of translation preinitiation complex by EPRS1 expression — LUNG_SCLC

Explore this box plot interactively →