EPRS1

Across TCGA cell cohorts, EPRS1 mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPRS1-associated genes across cancer lineages are OR2A2, CLPS, and CHST9. Each is linked with EPRS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPRS1-to-partner and partner-to-EPRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A2 grouped by EPRS1-low versus EPRS1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPRS1→partner) and Y-score (partner→EPRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	2
SOFT_TISSUE	CLPS →	+0.092	+4.392	<.001	.004	3	2
BLOOD_Leukemia	CHST9 →	+0.020	+3.551	<.001	.008	3	2
LARGE_INTESTINE	PRDM16 →	+0.923	+3.628	<.001	<.001	3	2
BREAST	DIPK2B →	+0.016	+4.357	<.001	.004	3	2
BREAST	LRRC38 →	+0.189	+4.071	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

OR2A2 by EPRS1 expression — URINARY_TRACT

Explore this box plot interactively →