EPPK1

Across TCGA pan-cancer cohorts, EPPK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EPPK1 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EPPK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EPPK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and PDAC are the cancer types where EPPK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	1.000	0.882	.002	58	view →
COAD	DFS	Median	All	1.000	0.883	.016	24	view →
PDAC	OS	Quartile	II,III,IV	0.595	0.242	<.001	22	view →
LUAD	OS	Median	II,III,IV	0.438	0.817	.001	20	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	18	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.508	.025	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EPPK1–HNSC (DFS)

Open the HNSC breakdown →