EPPK1

Across TCGA patient cohorts, EPPK1 mutation is significantly associated with the RNA expression of many other genes, with 5,796 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPPK1-associated genes across cancer lineages are NARS1, BUB3, and SETBP1-DT. Each is linked with EPPK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPPK1-to-partner and partner-to-EPPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NARS1 grouped by EPPK1-low versus EPPK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPPK1→partner) and Y-score (partner→EPPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NARS1 →	+0.419	+2.615	.001	.005	3	5
UCEC	BUB3 →	+0.391	+2.145	<.001	<.001	3	5
SKCM	SETBP1-DT →	-0.221	-0.980	.009	.006	3	4
LUSC	NDUFA5 →	+0.497	+3.369	<.001	.005	3	4
COAD	RPL23AP82 →	+0.392	+3.472	<.001	.002	3	4
COAD	BCCIP →	+0.341	+1.933	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,796 associations by consensus.

NARS1 by EPPK1 expression — COAD

Explore this box plot interactively →