EPPK1

Across TCGA patient cohorts, EPPK1 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPPK1-associated genes across cancer lineages are FASN, INPP4B, and FoxM1. Each is linked with EPPK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPPK1-to-partner and partner-to-EPPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by EPPK1-low versus EPPK1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPPK1→partner) and Y-score (partner→EPPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FASN →	+0.589	+2.459	.010	.020	3	5
SKCM	INPP4B →	-0.116	-1.209	.032	.029	3	4
STAD	FoxM1 →	+0.302	+2.321	.003	.030	3	3
STAD	Caveolin-1 →	-0.843	-3.321	.004	.008	3	3
UCEC	Cyclin-B1 →	+0.735	+1.807	<.001	<.001	3	3
COAD	PKC-a_pS657 →	-0.331	-1.991	.008	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

FASN by EPPK1 expression — BLCA

Explore this box plot interactively →