EPPK1

Across TCGA cell cohorts, EPPK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,064 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible EPPK1-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Mitotic G1/S transition checkpoint signaling, and Bundle of His cell to Purkinje myocyte communication. Each is linked with EPPK1 in more than 11 cancer types. Because this analysis shows association rather than direction, both EPPK1-to-partner and partner-to-EPPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by EPPK1-low versus EPPK1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPPK1→partner) and Y-score (partner→EPPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.196	+2.810	<.001	<.001	3	12
STOMACH	Mitotic G1/S transition checkpoint signaling →	+0.108	+2.373	<.001	.001	3	11
URINARY_TRACT	Bundle of His cell to Purkinje myocyte communication →	+0.584	+2.190	.006	<.001	3	11
OESOPHAGUS	Establishment or maintenance of epithelial cell apical/basal polarity →	+0.122	+1.549	.004	<.001	3	11
STOMACH	Regulation of Notch signaling pathway →	+0.070	+2.294	.001	<.001	3	11
STOMACH	Desmosome organization →	+0.516	+2.401	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,064 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by EPPK1 expression — STOMACH

Explore this box plot interactively →