EPPK1

Across TCGA cell cohorts, EPPK1 mutation is significantly associated with the RNA expression of many other genes, with 1,707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPPK1-associated genes across cancer lineages are SYT12, PIM3, and PYURF. Each is linked with EPPK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPPK1-to-partner and partner-to-EPPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYT12 grouped by EPPK1-low versus EPPK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPPK1→partner) and Y-score (partner→EPPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYT12 →	+0.225	+2.385	<.001	.003	3	3
BREAST	PIM3 →	+0.851	+3.269	<.001	.001	3	3
LARGE_INTESTINE	PYURF →	+0.452	+1.891	<.001	<.001	3	3
LARGE_INTESTINE	PLIN2 →	-1.449	-3.169	.005	.006	3	3
LARGE_INTESTINE	GKAP1 →	+0.693	+1.545	<.001	.004	3	3
LARGE_INTESTINE	HSD17B6 →	+0.721	+2.459	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

SYT12 by EPPK1 expression — BLOOD_Leukemia

Explore this box plot interactively →