EPN3

Across TCGA pan-cancer cohorts, EPN3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EPN3 data layer compared with 19 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EPN3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EPN3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where EPN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.833	.003	44	view →
LUAD	OS	Median	II,III,IV	1.000	0.914	.017	10	view →
HNSC	OS	Tertile	III,IV	1.000	0.339	.027	4	view →
PDAC	DFS	Tertile	All	0.822	0.710	.029	3	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EPN3–UCEC (OS)

Open the UCEC breakdown →