EPN3

Across TCGA patient cohorts, EPN3 mutation is significantly associated with the RNA expression of many other genes, with 1,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPN3-associated genes across cancer lineages are RNU4ATAC14P, H3Y1, and NUDT4B. Each is linked with EPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN3-to-partner and partner-to-EPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4ATAC14P grouped by EPN3-low versus EPN3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN3→partner) and Y-score (partner→EPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU4ATAC14P →	+0.584	+6.245	<.001	.001	3	2
UCEC	H3Y1 →	+0.797	+1.874	<.001	.006	3	2
CESC	NUDT4B →	+0.088	+4.409	<.001	.006	3	2
SKCM	RNU2-15P →	+0.084	+4.411	<.001	.005	3	2
SKCM	RNU6-1245P →	+0.258	+2.858	<.001	.007	3	2
BLCA	SLC44A3P1 →	+0.028	+4.289	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,341 associations by consensus.

RNU4ATAC14P by EPN3 expression — LGG

Explore this box plot interactively →