EPN3

Across TCGA patient cohorts, EPN3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPN3-associated genes across cancer lineages are EGFR_pY1068, MEK1, and MSH2. Each is linked with EPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN3-to-partner and partner-to-EPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EPN3-low versus EPN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN3→partner) and Y-score (partner→EPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.251	-2.807	.022	.003	3	1
UCEC	MEK1 →	+0.515	+2.807	.001	.003	3	1
UCEC	MSH2 →	-0.403	-2.433	<.001	.018	3	1
UCEC	Myosin-IIa_pS1943 →	+0.203	+2.128	.024	.010	3	1
UCEC	Myosin-IIa →	+0.164	+1.592	.043	.044	3	1
UCEC	Notch1 →	+0.234	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by EPN3 expression — UCEC

Explore this box plot interactively →