EPN3

Across TCGA cell cohorts, EPN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,462 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible EPN3-associated GO terms across cancer lineages are Positive regulation of brown fat cell differentiation, Cytotoxic T cell degranulation, and Cell-cell adhesion mediated by cadherin. Each is linked with EPN3 in more than 10 cancer types. Because this analysis shows association rather than direction, both EPN3-to-partner and partner-to-EPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of brown fat cell differentiation grouped by EPN3-low versus EPN3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN3→partner) and Y-score (partner→EPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of brown fat cell differentiation →	+0.129	+2.556	<.001	<.001	3	11
URINARY_TRACT	Cytotoxic T cell degranulation →	+0.246	+3.063	<.001	<.001	3	11
STOMACH	Cell-cell adhesion mediated by cadherin →	+0.217	+2.997	<.001	<.001	3	11
URINARY_TRACT	NMDA selective glutamate receptor signaling pathway →	+0.369	+2.878	<.001	<.001	3	11
URINARY_TRACT	Basolateral protein secretion →	+0.276	+3.284	<.001	<.001	3	11
LIVER	Regulation of atrial cardiac muscle cell membrane depolarization →	-2.090	-0.552	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,462 associations by consensus.

Positive regulation of brown fat cell differentiation by EPN3 expression — OVARY

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