EPN3

Across TCGA cell cohorts, EPN3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible EPN3-associated genes across cancer lineages are GHRHR, PRSS55, and COX8C. Each is linked with EPN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN3-to-partner and partner-to-EPN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by EPN3-low versus EPN3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN3→partner) and Y-score (partner→EPN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GHRHR →	+0.052	+4.087	<.001	.009	3	1
URINARY_TRACT	PRSS55 →	+0.013	+4.217	.001	.005	3	1
URINARY_TRACT	COX8C →	+0.083	+4.217	<.001	.005	3	1
URINARY_TRACT	TCP11X2 →	+0.092	+4.087	.002	.009	3	1
URINARY_TRACT	TCP11X1 →	+0.021	+4.584	<.001	.002	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GHRHR by EPN3 expression — URINARY_TRACT

Explore this box plot interactively →