EPN2

Across TCGA pan-cancer cohorts, EPN2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of EPN2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EPN2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types EPN2 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and CCRCC are the cancer types where EPN2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPN2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.408	<.001	10	view →
LUAD	Male	III,IV	−0.581	<.001	9	view →
CCRCC	Male	IV	−0.271	<.001	9	view →
LSCC	Male	III,IV	−0.856	<.001	8	view →
HNSC	Male	III,IV	−0.275	<.001	8	view →
PDAC	Male	II,III,IV	+0.251	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

EPN2–COAD

Open the COAD breakdown →