EPN2

Across TCGA patient cohorts, EPN2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPN2-associated genes across cancer lineages are EGFR_pY1068, p38-MAPK_pT180_Y182, and p62 Lck ligand. Each is linked with EPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN2-to-partner and partner-to-EPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EPN2-low versus EPN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN2→partner) and Y-score (partner→EPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.245	-2.000	.005	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.414	-1.906	.009	.015	3	2
UCEC	p62 Lck ligand →	+0.345	+2.392	.002	<.001	3	2
UCEC	P-Cadherin →	-0.141	-2.584	.005	.010	3	2
UCEC	PCNA →	+0.217	+1.678	.004	.021	3	2
UCEC	Src_pY527 →	-0.342	-2.584	.024	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR_pY1068 by EPN2 expression — UCEC

Explore this box plot interactively →