EPN2

Across TCGA cell cohorts, EPN2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPN2-associated genes across cancer lineages are CST9L, RLN3, and CALHM4. Each is linked with EPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN2-to-partner and partner-to-EPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9L grouped by EPN2-low versus EPN2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN2→partner) and Y-score (partner→EPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR10T2 →	+0.830	+4.276	<.001	.007	3	1
LARGE_INTESTINE	ARL1 →	+0.497	+3.064	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CST9L by EPN2 expression — SOFT_TISSUE

Explore this box plot interactively →