EPN1

Across TCGA pan-cancer cohorts, EPN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EPN1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EPN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EPN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where EPN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.665	0.959	.005	19	view →
CCRCC	OS	Tertile	II,III,IV	1.000	0.212	.022	5	view →
HNSC	OS	Median	IV	0.598	0.855	.010	4	view →
UCEC	OS	Tertile	II,III,IV	0.349	0.889	.042	4	view →
GBM	OS	Median	All	0.949	0.765	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EPN1–LSCC (OS)

Open the LSCC breakdown →