EPN1

Across TCGA patient cohorts, EPN1 mutation is significantly associated with the RNA expression of many other genes, with 3,296 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPN1-associated genes across cancer lineages are CANT1, OIP5, and MRPS7. Each is linked with EPN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPN1-to-partner and partner-to-EPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CANT1 grouped by EPN1-low versus EPN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN1→partner) and Y-score (partner→EPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CANT1 →	+0.536	+3.210	.002	.009	3	3
UCEC	OIP5 →	+0.792	+1.914	<.001	<.001	3	3
UCEC	MRPS7 →	+0.316	+3.742	.006	<.001	3	3
UCEC	PSMC3IP →	+0.587	+3.108	<.001	<.001	3	3
UCEC	CCAR2 →	+0.337	+3.256	.009	<.001	3	3
UCEC	BIRC5 →	+0.639	+2.534	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,296 associations by consensus.

CANT1 by EPN1 expression — COAD

Explore this box plot interactively →