EPN1

Across TCGA patient cohorts, EPN1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPN1-associated genes across cancer lineages are FoxM1, ACC1, and Notch1. Each is linked with EPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN1-to-partner and partner-to-EPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by EPN1-low versus EPN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN1→partner) and Y-score (partner→EPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.190	+1.440	.034	.024	3	2
UCEC	ACC1 →	+0.280	+1.440	.026	.024	3	2
UCEC	Notch1 →	+0.180	+1.775	<.001	.007	3	2
COAD	TFRC →	+0.518	+2.195	.038	.034	3	2
UCEC	ATM →	-0.549	-1.752	<.001	.011	3	2
UCEC	eIF4E →	+0.190	+3.472	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FoxM1 by EPN1 expression — UCEC

Explore this box plot interactively →