EPN1

Across TCGA cell cohorts, EPN1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPN1-associated genes across cancer lineages are GAGE12E, TBC1D3H, and NLRP8. Each is linked with EPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPN1-to-partner and partner-to-EPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12E grouped by EPN1-low versus EPN1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPN1→partner) and Y-score (partner→EPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TBC1D3H →	+0.023	+4.643	<.001	.008	3	1
SKIN	NLRP8 →	+0.033	+4.977	<.001	.007	3	1
SKIN	KIR2DS4 →	+0.013	+5.415	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	PPP1R2C →	+0.022	+4.736	<.001	.009	3	1
STOMACH	PIRT →	+0.062	+4.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GAGE12E by EPN1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →