EPM2AIP1

Across TCGA patient cohorts, EPM2AIP1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPM2AIP1-associated genes across cancer lineages are 14-3-3_beta, ACVRL1, and Akt_pS473. Each is linked with EPM2AIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPM2AIP1-to-partner and partner-to-EPM2AIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EPM2AIP1-low versus EPM2AIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPM2AIP1→partner) and Y-score (partner→EPM2AIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.077	-1.780	.029	.024	3	2
UCEC	ACVRL1 →	-0.141	-3.980	.003	<.001	3	2
UCEC	Akt_pS473 →	+0.570	+1.362	.024	.037	3	2
UCEC	p38-MAPK →	-0.160	-2.202	.005	.010	3	2
UCEC	Akt_pT308 →	+0.577	+2.584	.009	.010	3	2
UCEC	p90 RSK →	+0.152	+1.817	.024	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by EPM2AIP1 expression — UCEC

Explore this box plot interactively →