EPM2A

Across TCGA patient cohorts, EPM2A protein abundance is significantly associated with the RNA expression of many other genes, with 9,922 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EPM2A-associated genes across cancer lineages are PGM5, EMCN, and SHE. Each is linked with EPM2A in more than 5 cancer types. Because this analysis shows association rather than direction, both EPM2A-to-partner and partner-to-EPM2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPM2A versus PGM5 in UCEC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPM2A→partner) and Y-score (partner→EPM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGM5 →	+1.130	+0.439	.001	.001	3	6
CCRCC	EMCN →	+1.405	+0.318	<.001	.008	3	6
BRCA	SHE →	+0.609	+0.448	.001	.003	3	6
HNSC	MYOM1 →	+1.375	+0.567	<.001	<.001	3	5
CCRCC	FHL5 →	+0.950	+0.292	.005	.005	3	5
GBM	EDNRB →	+1.626	+0.509	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,922 associations by consensus.

EPM2A vs PGM5 — UCEC

Explore this scatter interactively →