EPM2A

Across TCGA patient cohorts, EPM2A mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPM2A-associated genes across cancer lineages are 14-3-3_beta, Ku80, and MEK1. Each is linked with EPM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both EPM2A-to-partner and partner-to-EPM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EPM2A-low versus EPM2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPM2A→partner) and Y-score (partner→EPM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.109	-3.143	.013	.018	3	1
UCEC	Ku80 →	+0.275	+1.598	.007	.044	3	1
UCEC	MEK1 →	+0.456	+3.459	.004	.005	3	1
UCEC	MSH6 →	-0.347	-2.999	.016	.035	3	1
UCEC	p62 Lck ligand →	+0.374	+3.179	.008	.010	3	1
UCEC	p70-S6K →	+0.200	+2.142	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

14-3-3_beta by EPM2A expression — UCEC

Explore this box plot interactively →