EPM2A

Across TCGA cell cohorts, EPM2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,867 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EPM2A-associated GO terms across cancer lineages are Regulation of chromosome organization, Positive regulation of double-strand break repair via homologous recombination, and Positive regulation of cytoplasmic translation. Each is linked with EPM2A in more than 14 cancer types. Because this analysis shows association rather than direction, both EPM2A-to-partner and partner-to-EPM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome organization grouped by EPM2A-low versus EPM2A-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPM2A→partner) and Y-score (partner→EPM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of chromosome organization →	+0.073	+1.051	<.001	<.001	3	15
BLOOD_Leukemia	Positive regulation of double-strand break repair via homologous recombination →	+0.061	+0.697	<.001	<.001	3	14
OVARY	Positive regulation of cytoplasmic translation →	+0.108	+0.675	.001	<.001	3	13
STOMACH	Nuclear transport →	+0.069	+0.682	.001	.003	3	13
LARGE_INTESTINE	Regulation of transcription initiation by RNA polymerase II →	+0.073	+0.883	<.001	<.001	3	13
OESOPHAGUS	Protein-DNA complex assembly →	+0.067	+0.762	<.001	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,867 associations by consensus.

Regulation of chromosome organization by EPM2A expression — BLOOD_Lymphoma

Explore this box plot interactively →