EPM2A

Across TCGA cell cohorts, EPM2A mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPM2A-associated genes across cancer lineages are VAX1, SSMEM1, and OR2T8. Each is linked with EPM2A in more than 1 cancer types. Because this analysis shows association rather than direction, both EPM2A-to-partner and partner-to-EPM2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAX1 grouped by EPM2A-low versus EPM2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPM2A→partner) and Y-score (partner→EPM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VAX1 →	+0.744	+3.519	<.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.029	.001	.006	3	1
LARGE_INTESTINE	OR2T8 →	+0.130	+3.584	.008	.004	3	1
LARGE_INTESTINE	PNMA3 →	+0.194	+2.781	<.001	.009	3	1
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

VAX1 by EPM2A expression — LARGE_INTESTINE

Explore this box plot interactively →