EPHX2

Across TCGA patient cohorts, EPHX2 mutation is significantly associated with the RNA expression of many other genes, with 2,113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHX2-associated genes across cancer lineages are MIR6853, LINC02091, and NOL12. Each is linked with EPHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX2-to-partner and partner-to-EPHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by EPHX2-low versus EPHX2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX2→partner) and Y-score (partner→EPHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.181	+7.473	<.001	.007	3	2
UCEC	LINC02091 →	-0.257	-2.732	.009	<.001	3	2
UCEC	NOL12 →	+0.382	+2.354	<.001	<.001	3	2
SKCM	DAPK3 →	+0.526	+2.328	<.001	.003	3	2
UCEC	CHAF1A →	+0.663	+3.850	<.001	<.001	3	2
SKCM	C19orf48 →	+0.611	+3.604	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,113 associations by consensus.

MIR6853 by EPHX2 expression — BRCA

Explore this box plot interactively →