EPHX2

Across TCGA patient cohorts, EPHX2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHX2-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and Caspase-8. Each is linked with EPHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX2-to-partner and partner-to-EPHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EPHX2-low versus EPHX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX2→partner) and Y-score (partner→EPHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.266	-3.459	.005	.005	3	2
UCEC	Shc_pY317 →	-0.219	-2.807	<.001	.003	3	2
UCEC	Caspase-8 →	-0.228	-3.780	.018	<.001	3	2
UCEC	Cyclin-B1 →	+0.559	+1.874	.009	.049	3	2
SKCM	Rab25 →	-0.264	-3.321	.044	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.188	-2.074	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by EPHX2 expression — UCEC

Explore this box plot interactively →