EPHX1

Across TCGA pan-cancer cohorts, EPHX1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EPHX1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EPHX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPHX1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where EPHX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.920	1.000	.028	7	view →
GBM	DFS	Quartile	All	0.250	0.509	.021	5	view →
CCRCC	DFS	Quartile	III,IV	0.307	0.814	.009	5	view →
LUAD	OS	Quartile	III,IV	1.000	0.232	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EPHX1–HNSC (DFS)

Open the HNSC breakdown →