EPHX1

Across TCGA patient cohorts, EPHX1 mutation is significantly associated with the RNA expression of many other genes, with 406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHX1-associated genes across cancer lineages are RN7SL397P, GSTA6P, and CCL5. Each is linked with EPHX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHX1-to-partner and partner-to-EPHX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL397P grouped by EPHX1-low versus EPHX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHX1→partner) and Y-score (partner→EPHX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL397P →	+0.147	+3.631	<.001	.002	3	2
UCEC	GSTA6P →	+0.077	+2.813	.001	.005	3	2
UCEC	CCL5 →	+1.983	+3.606	<.001	.001	3	1
UCEC	MICE →	+0.517	+2.577	<.001	.009	3	1
UCEC	IGKV2-40 →	+0.391	+2.631	<.001	.007	3	1
UCEC	YWHAEP7 →	-0.517	-3.563	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 406 associations by consensus.

RN7SL397P by EPHX1 expression — SKCM

Explore this box plot interactively →