EPHB6

Across TCGA patient cohorts, EPHB6 mutation is significantly associated with the RNA expression of many other genes, with 6,468 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHB6-associated genes across cancer lineages are CCNB2, KMT5A, and FAM72B. Each is linked with EPHB6 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPHB6-to-partner and partner-to-EPHB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by EPHB6-low versus EPHB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB6→partner) and Y-score (partner→EPHB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.663	+1.807	<.001	<.001	3	5
UCEC	KMT5A →	+0.460	+1.638	<.001	<.001	3	4
COAD	FAM72B →	+0.502	+3.222	.003	.008	3	4
COAD	RNA5SP477 →	+0.726	+2.273	<.001	.002	3	4
UCEC	OIP5 →	+0.845	+2.021	<.001	<.001	3	4
UCEC	TIMM44 →	+0.327	+2.850	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,468 associations by consensus.

CCNB2 by EPHB6 expression — UCEC

Explore this box plot interactively →