EPHB6

Across TCGA patient cohorts, EPHB6 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHB6-associated genes across cancer lineages are mTOR_pS2448, C-Raf, and Stathmin. Each is linked with EPHB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHB6-to-partner and partner-to-EPHB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by EPHB6-low versus EPHB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB6→partner) and Y-score (partner→EPHB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.143	-1.787	.001	.003	3	4
UCEC	C-Raf →	+0.137	+2.070	.001	.001	3	3
COAD	Stathmin →	+0.243	+2.820	<.001	.035	3	3
UCEC	PCNA →	+0.242	+1.807	<.001	<.001	3	3
LUAD	Fibronectin →	+0.369	+1.584	.030	.032	3	2
LUAD	AMPK_alpha →	-0.117	-1.807	.031	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

mTOR_pS2448 by EPHB6 expression — UCEC

Explore this box plot interactively →