EPHB6

Across TCGA cell cohorts, EPHB6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,856 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPHB6-associated GO terms across cancer lineages are Striated muscle contraction, Regulation of mitotic spindle assembly, and ESCRT complex disassembly. Each is linked with EPHB6 in more than 9 cancer types. Because this analysis shows association rather than direction, both EPHB6-to-partner and partner-to-EPHB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Striated muscle contraction grouped by EPHB6-low versus EPHB6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB6→partner) and Y-score (partner→EPHB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Striated muscle contraction →	+0.111	+1.138	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of mitotic spindle assembly →	+0.122	+2.695	.002	.004	2	10
BLOOD_Leukemia	ESCRT complex disassembly →	+0.097	+3.107	<.001	<.001	3	8
BLOOD_Leukemia	ESCRT III complex disassembly →	+0.097	+3.107	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of spindle assembly →	+0.101	+2.867	.002	.002	3	8
PANCREAS	Release of cytochrome c from mitochondria →	+0.116	+2.170	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,856 associations by consensus.

Striated muscle contraction by EPHB6 expression — SOFT_TISSUE

Explore this box plot interactively →