EPHB6

Across TCGA cell cohorts, EPHB6 mutation is significantly associated with the RNA expression of many other genes, with 939 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPHB6-associated genes across cancer lineages are FAM13A, SETD7, and BCL7A. Each is linked with EPHB6 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHB6-to-partner and partner-to-EPHB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM13A grouped by EPHB6-low versus EPHB6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB6→partner) and Y-score (partner→EPHB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM13A →	+1.109	+3.169	.001	.006	3	2
LUNG_NSCLC_LUAD	SETD7 →	+0.638	+3.321	.009	.004	3	2
BLOOD_Leukemia	BCL7A →	+1.290	+3.489	.003	.001	3	2
BLOOD_Leukemia	AKAP3 →	+0.701	+3.115	<.001	.009	3	2
BLOOD_Leukemia	LLGL1 →	+1.062	+3.489	<.001	.001	3	2
BLOOD_Leukemia	TMEM106C →	+0.854	+3.228	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 939 associations by consensus.

FAM13A by EPHB6 expression — LARGE_INTESTINE

Explore this box plot interactively →