Across TCGA pan-cancer cohorts, EPHB4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EPHB4 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher EPHB4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EPHB4 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where EPHB4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.886	.020	30	view →
CCRCC	DFS	Median	IV	0.908	0.131	.004	27	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.863	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: EPHB4 tumor-vs-normal RNA expression · all EPHB4 data types