Across TCGA patient cohorts, EPHB4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,424 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible EPHB4-associated proteins across cancer lineages are MEPCE, NAT10, and SMARCA5. Each is linked with EPHB4 in more than 5 cancer types. Because this analysis shows association rather than direction, both EPHB4-to-partner and partner-to-EPHB4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB4→partner) and Y-score (partner→EPHB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEPCE →	+0.425	+0.774	<.001	<.001	3	6
HNSC	NAT10 →	+0.275	+0.752	.001	.001	3	5
LSCC	SMARCA5 →	+0.262	+0.682	.002	<.001	3	5
LSCC	ZMYM3_S464 →	+0.403	+0.572	<.001	.001	3	5
LSCC	GPRIN3 →	-0.393	-0.531	<.001	<.001	3	5
HNSC	GTF2I →	+0.388	+0.620	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,424 associations by consensus.

Exploration

EPHB4 survival (RNA) · tumor vs normal (RNA) · all EPHB4 data types