Across TCGA patient cohorts, EPHB4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,959 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EPHB4-associated genes across cancer lineages are TRIP6, ZNF3, and ARMC10. Each is linked with EPHB4 in more than 5 cancer types. Because this analysis shows association rather than direction, both EPHB4-to-partner and partner-to-EPHB4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB4→partner) and Y-score (partner→EPHB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIP6 →	+0.994	+0.415	<.001	<.001	3	6
HNSC	ZNF3 →	+0.902	+0.442	<.001	<.001	3	5
HNSC	ARMC10 →	+0.698	+0.413	<.001	<.001	3	5
LSCC	BAIAP2L1 →	+0.756	+0.468	<.001	<.001	3	5
LSCC	SYPL1 →	+1.071	+0.521	<.001	<.001	3	5
HNSC	AP1S1 →	+0.899	+0.351	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,959 associations by consensus.

Exploration

EPHB4 survival (RNA) · tumor vs normal (RNA) · all EPHB4 data types