Across TCGA patient cohorts, EPHB4 mutation is significantly associated with the RNA expression of many other genes, with 4,039 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHB4-associated genes across cancer lineages are NPAP1P2, MRPS17P9, and KRT8P50. Each is linked with EPHB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHB4-to-partner and partner-to-EPHB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB4→partner) and Y-score (partner→EPHB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	NPAP1P2 →	+0.047	+4.887	<.001	.009	3	3
ACC	MRPS17P9 →	+0.121	+5.228	<.001	.005	3	3
COAD	KRT8P50 →	+0.140	+3.281	<.001	.001	3	3
CESC	PPP1R9A-AS1 →	+0.105	+3.718	<.001	<.001	3	3
UCEC	PKM →	+0.477	+2.584	<.001	<.001	3	3
CESC	RPL35AP30 →	+0.078	+3.273	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,039 associations by consensus.

Exploration

EPHB4 survival (RNA) · tumor vs normal (RNA) · all EPHB4 data types