Across TCGA cell cohorts, EPHB4 mutation is significantly associated with the RNA expression of many other genes, with 281 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHB4-associated genes across cancer lineages are SCGB1C1, ELOA3DP, and TCP10L2. Each is linked with EPHB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHB4-to-partner and partner-to-EPHB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB4→partner) and Y-score (partner→EPHB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCGB1C1 →	+0.104	+4.539	<.001	.007	3	2
LARGE_INTESTINE	ELOA3DP →	+0.022	+2.425	<.001	.004	3	2
LUNG_NSCLC_LUAD	TCP10L2 →	+0.064	+4.887	<.001	.009	3	2
CNS	OR8B4 →	+0.036	+4.772	<.001	.002	3	2
BLOOD_Lymphoma	PPIAL4D →	+0.174	+2.681	<.001	.007	3	2
LIVER	RFPL3 →	+0.038	+3.459	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

Exploration

EPHB4 survival (RNA) · tumor vs normal (RNA) · all EPHB4 data types