EPHB3

Across TCGA pan-cancer cohorts, EPHB3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EPHB3 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EPHB3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EPHB3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where EPHB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	1.000	0.858	.002	20	view →
CCRCC	DFS	Median	All	0.964	0.811	.015	6	view →
LSCC	DFS	Median	All	0.718	0.859	.024	3	view →
LUAD	DFS	Tertile	All	1.000	0.572	.013	2	view →
UCEC	OS	Tertile	All	0.971	0.845	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EPHB3–HNSC (DFS)

Open the HNSC breakdown →