EPHB3

Across TCGA patient cohorts, EPHB3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,905 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EPHB3-associated genes across cancer lineages are CLEC6A, PIM2, and MAP4K1. Each is linked with EPHB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both EPHB3-to-partner and partner-to-EPHB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPHB3 versus CLEC6A in LSCC, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB3→partner) and Y-score (partner→EPHB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLEC6A →	-0.705	-0.519	<.001	<.001	3	6
HNSC	PIM2 →	-1.233	-0.424	<.001	<.001	3	5
HNSC	MAP4K1 →	-1.039	-0.500	<.001	<.001	3	5
HNSC	LY9 →	-0.903	-0.546	<.001	<.001	3	5
UCEC	FBXL8 →	+0.632	+0.760	.004	.009	3	5
HNSC	IRF4 →	-1.038	-0.467	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,905 associations by consensus.

EPHB3 vs CLEC6A — LSCC

Explore this scatter interactively →