EPHB3

Across TCGA cell cohorts, EPHB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,957 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EPHB3-associated GO terms across cancer lineages are Establishment or maintenance of epithelial cell apical/basal polarity, Negative regulation of DNA-templated transcription initiation, and Megakaryocyte differentiation. Each is linked with EPHB3 in more than 10 cancer types. Because this analysis shows association rather than direction, both EPHB3-to-partner and partner-to-EPHB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment or maintenance of epithelial cell apical/basal polarity grouped by EPHB3-low versus EPHB3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB3→partner) and Y-score (partner→EPHB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Establishment or maintenance of epithelial cell apical/basal polarity →	+0.125	+1.968	.002	.001	3	11
OESOPHAGUS	Negative regulation of DNA-templated transcription initiation →	+0.123	+2.458	.003	<.001	3	10
LIVER	Megakaryocyte differentiation →	-0.150	-1.562	<.001	.001	3	10
OESOPHAGUS	Establishment or maintenance of apical/basal cell polarity →	+0.134	+2.239	.002	<.001	3	10
OESOPHAGUS	Negative regulation of transcription initiation by RNA polymerase II →	+0.123	+2.458	.003	<.001	3	10
OESOPHAGUS	Establishment or maintenance of bipolar cell polarity →	+0.134	+2.239	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,957 associations by consensus.

Establishment or maintenance of epithelial cell apical/basal polarity by EPHB3 expression — OESOPHAGUS

Explore this box plot interactively →