EPHB3

Across TCGA cell cohorts, EPHB3 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHB3-associated genes across cancer lineages are CDH20, RFPL3, and HOXD9. Each is linked with EPHB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHB3-to-partner and partner-to-EPHB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by EPHB3-low versus EPHB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB3→partner) and Y-score (partner→EPHB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.096	+2.807	<.001	.005	3	1
LARGE_INTESTINE	RFPL3 →	+0.036	+2.510	<.001	.004	3	1
LARGE_INTESTINE	HOXD9 →	+1.172	+3.234	<.001	.005	3	1
LARGE_INTESTINE	TXNDC17 →	+0.761	+3.212	.002	.006	3	1
LARGE_INTESTINE	NFATC1 →	+1.142	+3.212	<.001	.006	3	1
LARGE_INTESTINE	GRTP1 →	-1.097	-3.169	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

CDH20 by EPHB3 expression — LARGE_INTESTINE

Explore this box plot interactively →